New treatment approach for gastric cancer targeting tumor fibrin
Official title: Theranostic for gastric cancer
Funded at Collagen Medical, LLC · NIH-11141271 · Data updated 2026-11-12
This study is looking at a new treatment for advanced gastric cancer that focuses on a substance called fibrin found in tumors, hoping to make the therapy more effective and improve outcomes for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Collagen Medical, LLC NIH-funded |
| Lab location | 1 site (Boston, UNITED STATES) |
| Project start | September 11, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $885,123 |
| NIH project number | 4R44CA275590-02 |
| Project ID | NIH-11141271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with advanced gastric cancer who have not responded well to standard therapies.
✕Less likely to help
Patients with early-stage gastric cancer or those whose tumors do not exhibit significant fibrin deposition may not benefit from this research.
What this research studies
This research aims to improve the management of gastric cancer by developing a therapy that targets fibrin in the tumor microenvironment. Gastric cancer is a serious condition with a poor prognosis, and current treatments have limited effectiveness. The approach involves using high energy beta particle radiotherapy specifically directed at fibrin, which is abundant in tumors but not in healthy tissues. By utilizing advanced imaging techniques, the therapy seeks to enhance treatment outcomes for patients with advanced gastric cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for gastric cancer, potentially improving survival rates and quality of life for patients.
How similar studies have gone: While targeting fibrin in tumors is a novel approach, similar strategies using targeted therapies have shown promise in other cancer types, suggesting potential for success in this area.
Where this research is happening
-
Collagen Medical, LLC
Boston, United States Active
Researchers
- Principal investigator: Humblet, Valerie — Collagen Medical, LLC
- Study coordinator: Humblet, Valerie
Related research
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Improved fibrin-targeted radiopharmaceutical for gastric cancer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.