New treatment approach for dental implant infections
Official title: Epigenetic Therapy of Periimplantitis
Funded at University of Rochester · NIH-11108313 · Data updated 2026-11-12
This study is looking at a new treatment to help prevent infections around dental implants, using rats to understand how the body reacts to these implants and how we can make things better for people who have them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $582,000 |
| NIH project number | 1R01DE034804-01 |
| Project ID | NIH-11108313 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have dental implants and are experiencing or at risk of peri-implantitis.
✕Less likely to help
Patients without dental implants or those who have not experienced any complications related to their implants may not benefit from this research.
What this research studies
This research investigates a novel epigenetic therapy aimed at addressing peri-implantitis, a common infection that can occur around dental implants. By utilizing a rat model, the study explores the biological mechanisms behind implant failure, particularly focusing on inflammation and bone loss caused by titanium particles. The researchers aim to identify how specific epigenetic changes influence the body's response to these implants, potentially leading to improved treatment strategies for patients with dental implants.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for preventing and managing infections around dental implants, improving patient outcomes.
How similar studies have gone: While the specific epigenetic approach is novel, previous studies have shown success in addressing implant-related infections through various therapeutic strategies.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Diekwisch, Tom — University of Rochester
- Study coordinator: Diekwisch, Tom
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.