New treatment approach for brain injury in newborns
Official title: Neuroprotective Strategy: Novel Purine Derivatives for Neonatal Hypoxia-ischemia
Funded at Women and Infants Hospital-Rhode Island · NIH-10786038 · Data updated 2026-11-12
This study is looking at a new type of medicine that could help protect newborns' brains from damage when they don't get enough oxygen, aiming to reduce inflammation and improve brain health, which could lead to better outcomes for babies affected by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Women and Infants Hospital-Rhode Island NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | May 1, 2021 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $444,404 |
| NIH project number | 5R01NS117428-04 |
| Project ID | NIH-10786038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns and infants who have experienced hypoxia-ischemia, particularly those in neonatal intensive care.
✕Less likely to help
Patients who are older than two years or those who have not experienced hypoxia-ischemia may not benefit from this research.
What this research studies
This research investigates a novel family of purine derivatives aimed at protecting the brain from damage caused by hypoxia-ischemia in newborns. The study focuses on understanding how these molecules can reduce inflammation and improve the integrity of the blood-brain barrier, which is crucial for brain health. By targeting specific pathways involved in neuroprotection, the research aims to enhance cognitive function and reduce brain injury in infants affected by this condition. If successful, this treatment could offer a new therapeutic option beyond current supportive care.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option that significantly improves outcomes for infants suffering from brain injuries due to hypoxia-ischemia.
How similar studies have gone: Previous studies have shown success with similar neuroprotective approaches in animal models, indicating potential for effective treatment in humans.
Where this research is happening
-
Women and Infants Hospital-Rhode Island
Providence, United States Active
Researchers
- Principal investigator: Chen, Xiaodi Felix — Women and Infants Hospital-Rhode Island
- Study coordinator: Chen, Xiaodi Felix
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.