New tools for studying protein movements and structures
Official title: DEER spectroscopy tools for probing protein conformational dynamics
Funded at University of Washington · NIH-11019798 · Data updated 2026-11-12
This study is working on new ways to use a special technique called DEER spectroscopy to better understand how proteins move and change, which is important for figuring out diseases and helping with drug development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $377,238 |
| NIH project number | 5R35GM151956-02 |
| Project ID | NIH-11019798 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction, such as certain genetic disorders or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein dynamics or those who do not have access to advanced biostructural analysis may not benefit from this research.
What this research studies
This research focuses on developing innovative methods for DEER spectroscopy, a technique that allows scientists to observe and quantify the movements and structures of proteins at a very small scale. By combining experimental techniques with advanced computational methods, the project aims to improve the analysis of protein dynamics, which are essential for understanding various biological processes and diseases. The research will also explore new ways to label proteins in their natural environments, enhancing the accuracy of the findings. Overall, this work seeks to provide valuable insights that could aid in drug development and other biomedical applications.
Why it matters
Potential benefit: If successful, this research could lead to better understanding of protein dynamics, potentially resulting in more effective drug therapies.
How similar studies have gone: Previous research has shown success in using advanced spectroscopy techniques to study protein dynamics, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Stoll, Stefan — University of Washington
- Study coordinator: Stoll, Stefan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.