New therapy for treating severe restless legs syndrome
Official title: Developing closed-loop tonic motor activation therapy for treatment of refractory restless legs syndrome
Funded at Noctrix Health, INC · NIH-11064926 · Data updated 2026-11-12
This study is testing a new therapy called CL-TOMAC that gently stimulates your nerves while you sleep to help manage Restless Legs Syndrome, making it easier for you to get a good night's rest without relying on medications that might have side effects.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Noctrix Health, INC NIH-funded |
| Lab location | 1 site (Pleasanton, UNITED STATES) |
| Project start | May 1, 2020 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $515,503 |
| NIH project number | 2R44NS117294-04 |
| Project ID | NIH-11064926 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who experience severe symptoms of restless legs syndrome and have not found relief with existing treatments.
✕Less likely to help
Patients who do not have restless legs syndrome or those whose symptoms are well-managed with current therapies may not benefit from this research.
What this research studies
This research focuses on developing a novel therapy called the Closed-Loop Tonic Motor Activation system (CL-TOMAC) to help manage Restless Legs Syndrome (RLS), a condition that disrupts sleep and affects quality of life. The approach involves non-invasive stimulation of peripheral nerves to automatically activate therapy during sleep based on detected leg movements. This method aims to reduce sleep disturbances and potentially lower the need for traditional medications, which often have undesirable side effects. The project will validate the effectiveness of this system in clinical settings.
Why it matters
Potential benefit: If successful, this research could significantly improve sleep quality and overall well-being for patients suffering from refractory restless legs syndrome.
How similar studies have gone: Previous research has shown promise with similar non-invasive stimulation therapies for RLS, indicating potential for success with this novel approach.
Where this research is happening
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Noctrix Health, INC
Pleasanton, United States Active
Researchers
- Principal investigator: Charlesworth, Jonathan David — Noctrix Health, INC
- Study coordinator: Charlesworth, Jonathan David
Related research
Other NIH-funded projects on the same topics.
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Closed-loop tonic motor activation therapy for refractory restless legs syndrome
A new, non-invasive treatment called CL-TOMAC would automatically activate therapy during sleep to reduce symptoms for adults with restless legs syndrome and help reduce sleep disruption and dependency on medications.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.