New tests to detect 1,4‑dioxane exposure and body responses
Evaluation of novel markers of exposure and biological response to 1,4-dioxane
This project develops new blood and urine tests to find exposure to 1,4‑dioxane and related chemicals in people living in affected communities.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11126081 on NIH RePORTER |
What this research studies
You would be part of work looking at drinking water and people’s bodies in areas where 1,4‑dioxane pollution is common. The team will measure 1,4‑dioxane and other solvents in water and in blood/urine samples and search for biological signs that the chemicals have affected the body. They will compare results from Long Island, New York (primary) with the Cape Fear River watershed, North Carolina (secondary). The goal is to create clearer ways to tell who was exposed and how the body responded.
Who could benefit from this research
Good fit: Adults (21+) who live in or get drinking water from areas of Long Island, NY or the Cape Fear River watershed, NC where 1,4‑dioxane contamination is suspected would be ideal candidates.
Not a fit: People younger than 21 or those living outside the contaminated areas with no likely tap-water exposure are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this could help identify people exposed to 1,4‑dioxane earlier and improve monitoring and public health responses.
How similar studies have performed: Human exposure data for 1,4‑dioxane are limited, so this approach is relatively new though biomonitoring has worked for related industrial solvents.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Deziel, Nicole — Yale University
- Study coordinator: Deziel, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.