New testing methods for detecting syphilis infections.
Official title: Rapid and Ultrasensitive aptamer-based detection technologies for T. pallidum
Funded at University of Washington · NIH-10942579 · Data updated 2026-11-12
This study is working on a quick and super-sensitive test for syphilis, which will make it easier and more accurate for people to get diagnosed, whether they are adults or newborns.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $233,250 |
| NIH project number | 1R21AI184484-01 |
| Project ID | NIH-10942579 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who may be at risk for syphilis infection or those who are pregnant and require testing for congenital syphilis.
✕Less likely to help
Patients who are not at risk for syphilis or those who have already been diagnosed and treated for the infection may not benefit from this research.
What this research studies
This research focuses on developing a rapid and ultrasensitive diagnostic test for Treponema pallidum, the bacteria that causes syphilis. The current testing methods are often slow, expensive, and can produce inaccurate results, leading to missed diagnoses. By utilizing aptamers—short DNA molecules that can bind to specific targets—this project aims to create a more efficient point-of-care testing solution that can be used widely and easily. This innovative approach seeks to improve the speed and accuracy of syphilis diagnosis, particularly in both adult and congenital cases.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate diagnoses of syphilis, improving patient outcomes and reducing the public health threat posed by this infection.
How similar studies have gone: Previous research has shown promise in using aptamer-based technologies for diagnostics, indicating potential success for this novel approach.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Salipante, Stephen J — University of Washington
- Study coordinator: Salipante, Stephen J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.