New technology to study how drugs interact with proteins
Official title: Technology for evaluating drug-binding responses to small-molecule perturbation
Funded at University of Washington · NIH-10931378 · Data updated 2026-11-12
This study is exploring new technology to see how well different drugs and molecules connect with proteins in our bodies, which could help improve how effective these treatments are for various health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 25, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $388,750 |
| NIH project number | 5R35GM150919-02 |
| Project ID | NIH-10931378 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that could benefit from improved drug therapies targeting specific protein interactions.
✕Less likely to help
Patients who are not currently seeking new treatments or those with conditions unrelated to protein-ligand interactions may not benefit from this research.
What this research studies
This research focuses on developing advanced technology to evaluate how drugs and other molecules bind to proteins, which are crucial for many biological functions. By using high-throughput methods, the project aims to analyze protein-ligand interactions across the entire set of human proteins in a single experiment. The approach involves measuring changes in protein stability when they bind to different ligands, allowing for a comprehensive understanding of these interactions. This could lead to better insights into drug efficacy and the biological processes they influence.
Why it matters
Potential benefit: If successful, this research could enhance the development of more effective drugs by providing deeper insights into how they interact with proteins in the body.
How similar studies have gone: Other research has shown promise in using high-throughput methods for studying protein interactions, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Schweppe, Devin Karl — University of Washington
- Study coordinator: Schweppe, Devin Karl
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.