New technology to measure metals in human bones without surgery
Highly Sensitive Novel Neutron Activation Analysis (NAA) Technology to Quantify Multiple Metals in Human Bone In Vivo
This study is testing a new way to safely measure metal levels in bones without any surgery, which could help us understand how metal exposure affects health over time, and patients may help us make this technology better for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11143667 on NIH RePORTER |
What this research studies
This research focuses on developing a novel technology called in vivo neutron activation analysis (IVNAA) to non-invasively measure the levels of various metals in human bones. By accurately quantifying metal body burden, the research aims to better understand the long-term health effects of metal exposure, which can lead to diseases over time. The project will address technical challenges to ensure the technology is sensitive and reproducible for real-world applications, ultimately benefiting broader communities. Patients may be involved in the validation process of this technology, which could lead to improved diagnostic methods for metal-related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with potential metal exposure or those experiencing symptoms related to metal toxicity.
Not a fit: Patients who do not have any history of metal exposure or related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, non-invasive method for diagnosing and monitoring metal toxicity in patients.
How similar studies have performed: While the approach of using neutron activation analysis is established, the specific application to non-invasively measure metals in human bones is innovative and has not been widely tested.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Nie, Linda H — Purdue University
- Study coordinator: Nie, Linda H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.