New technology to measure how proteins interact on single cells
Plasmonic Scattering Microscopy for high-throughput in-situ quantification of molecular binding kinetics on single cells
['FUNDING_OTHER'] · BIOSENSING INSTRUMENT, INC. · NIH-11008269
This study is testing a new imaging technique to watch how proteins on the surface of single cells interact in real-time, which could help scientists better understand these proteins and develop new treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BIOSENSING INSTRUMENT, INC. (nih funded) |
| Locations | 1 site (TEMPE, UNITED STATES) |
| Trial ID | NIH-11008269 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel imaging technique called Plasmonic Scattering Microscopy (PSM) to measure the interactions of membrane proteins on single cells in real-time. By observing these interactions in their natural environment, the research aims to provide more accurate data for understanding protein functions and discovering new biomarkers. This method eliminates the need for labor-intensive extraction and purification processes, allowing for high-throughput analysis that could accelerate drug development. Patients may benefit from advancements in drug therapies that arise from a better understanding of how drugs interact with cellular receptors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve membrane protein dysfunction or those who may benefit from new drug therapies targeting these proteins.
Not a fit: Patients who do not have conditions related to membrane proteins or who are not seeking new drug therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to faster and more effective drug development, improving treatment options for patients.
How similar studies have performed: While similar techniques like Surface Plasmon Resonance Microscopy have been used, this specific approach with PSM is considered a novel advancement.
Where this research is happening
TEMPE, UNITED STATES
- BIOSENSING INSTRUMENT, INC. — TEMPE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LY, NGUYEN — BIOSENSING INSTRUMENT, INC.
- Study coordinator: LY, NGUYEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.