New technology to measure how proteins interact on single cells
Official title: Plasmonic Scattering Microscopy for high-throughput in-situ quantification of molecular binding kinetics on single cells
Funded at Biosensing Instrument, INC. · NIH-11008269 · Data updated 2026-11-12
This study is testing a new imaging technique to watch how proteins on the surface of single cells interact in real-time, which could help scientists better understand these proteins and develop new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Biosensing Instrument, INC. NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | September 1, 2024 |
| Project end | August 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $295,561 |
| NIH project number | 1R42GM154550-01A1 |
| Project ID | NIH-11008269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve membrane protein dysfunction or those who may benefit from new drug therapies targeting these proteins.
✕Less likely to help
Patients who do not have conditions related to membrane proteins or who are not seeking new drug therapies may not benefit from this research.
What this research studies
This research focuses on developing a novel imaging technique called Plasmonic Scattering Microscopy (PSM) to measure the interactions of membrane proteins on single cells in real-time. By observing these interactions in their natural environment, the research aims to provide more accurate data for understanding protein functions and discovering new biomarkers. This method eliminates the need for labor-intensive extraction and purification processes, allowing for high-throughput analysis that could accelerate drug development. Patients may benefit from advancements in drug therapies that arise from a better understanding of how drugs interact with cellular receptors.
Why it matters
Potential benefit: If successful, this research could lead to faster and more effective drug development, improving treatment options for patients.
How similar studies have gone: While similar techniques like Surface Plasmon Resonance Microscopy have been used, this specific approach with PSM is considered a novel advancement.
Where this research is happening
-
Biosensing Instrument, INC.
Tempe, United States Active
Researchers
- Principal investigator: Ly, Nguyen — Biosensing Instrument, INC.
- Study coordinator: Ly, Nguyen
Related research
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A new technology to measure how drugs bind to important proteins in cells
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.