New technology to analyze virus particles for better gene therapy delivery
Official title: Multimodal Label-Free Nanosensor for Single Virus Characterization and Content Analysis
Funded at Southern Methodist University · NIH-10933401 · Data updated 2026-11-12
This study is working on a new tiny sensor that helps check the quality of viruses used in gene therapy, making sure patients get the right amount for safe and effective treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Methodist University NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 25, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $403,348 |
| NIH project number | 5R01GM149949-02 |
| Project ID | NIH-10933401 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients requiring gene therapy for conditions like hereditary blindness or other genetic disorders.
✕Less likely to help
Patients who do not require gene therapy or are not affected by conditions treatable with AAVs may not benefit from this research.
What this research studies
This research focuses on developing a novel nanosensor that can accurately characterize adeno-associated viruses (AAVs), which are used in gene therapy. The approach involves using a plasmonic nanopore sensor combined with optical trapping to determine the content of these viruses, ensuring that the right dosage is delivered for effective treatment. By analyzing the deformation of virus capsids, the researchers aim to improve the quality control of viral vectors, which is crucial for safe and effective gene therapies. This method seeks to provide a more reliable alternative to existing techniques that have shown inconsistencies.
Why it matters
Potential benefit: If successful, this research could enhance the safety and effectiveness of gene therapies by ensuring accurate delivery of viral vectors.
How similar studies have gone: Previous research has shown promise in using nanopore technology for virus characterization, indicating potential success for this novel approach.
Where this research is happening
-
Southern Methodist University
Dallas, United States Active
Researchers
- Principal investigator: Kim, Minjun — Southern Methodist University
- Study coordinator: Kim, Minjun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.