New technology for treating inoperable liver tumors
Official title: Feasibility of a Multi-Phase Algorithmic Non-Thermal Ablation Technology for the Treatment of Inoperable Tumors
Funded at Gradient Medical, INC. · NIH-10547371 · Data updated 2026-11-12
This study is testing a new, gentle treatment called PACE that uses quick electrical pulses to help destroy hard-to-reach liver tumors, and it's designed for patients whose tumors can't be removed with surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Gradient Medical, INC. NIH-funded |
| Lab location | 1 site (Cary, United States) |
| Project start | September 16, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $259,549 |
| NIH project number | 1R41CA275587-01 |
| Project ID | NIH-10547371 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with inoperable liver tumors who are not suitable for surgical resection.
✕Less likely to help
Patients with operable liver tumors or those who have other medical conditions that preclude them from receiving this type of treatment may not benefit.
What this research studies
This research investigates a novel minimally invasive technique called Phased Algorithmically Controlled Electrotherapy (PACE) for treating inoperable liver tumors. The approach uses ultrashort high-intensity electrical pulses to disrupt cancer cells, leading to cell death. The study aims to develop a specialized pulse generation system and assess how effectively it can target liver tumors. Patients with liver tumors that cannot be surgically removed may benefit from this innovative treatment method.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for patients with inoperable liver tumors, potentially improving survival rates.
How similar studies have gone: While this approach is innovative, similar techniques using electrical pulses for tumor treatment have shown promise in preliminary studies.
Where this research is happening
-
Gradient Medical, INC.
Cary, United States Active
Researchers
- Principal investigator: Fong, Jordan — Gradient Medical, INC.
- Study coordinator: Fong, Jordan
Related research
Other NIH-funded projects on the same topics.
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Commercial INSPIRE pulse technology for treating inoperable tumors
A new non-thermal cancer treatment called INSPIRE uses ultra-short electrical pulses to kill tumor cells near delicate body structures, helping patients who can’t have surgery.
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A non‑heat electrical treatment for tumors that can’t be removed by surgery
This project is developing a non‑thermal electric device to treat people with hard‑to‑remove lung, liver, or pancreatic tumors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.