New technology for recording brain cell activity and manipulating specific cell types
Neuropixels Opto: Integrated Silicon Probes for Cell-Type-Specific Electrophysiology
['FUNDING_U01'] · ALLEN INSTITUTE · NIH-10908651
This study is testing a new tool that helps scientists see how different brain cells work and how they might be involved in brain diseases by using light to stimulate specific cells, which could lead to better understanding and treatments for conditions affecting the brain.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALLEN INSTITUTE (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10908651 on ClinicalTrials.gov |
What this research studies
This research focuses on developing an advanced tool called Neuropixels Opto, which combines high-density electrophysiological recording with the ability to deliver light to specific brain cells. By using this technology, researchers aim to identify different types of neurons and understand their roles in brain function and disease. The approach involves a technique known as 'optotagging' to manipulate genetically defined neural populations, allowing for a deeper understanding of how these cells contribute to behavior and neurological conditions. The project will utilize cutting-edge fabrication techniques to create a device that can record from thousands of neurons simultaneously while also enabling targeted light stimulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may benefit from targeted brain interventions or those interested in the underlying mechanisms of brain function.
Not a fit: Patients with conditions unrelated to neuronal activity or those who do not have access to the research facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain function and developing targeted therapies for neurological disorders.
How similar studies have performed: Other research has shown promise with similar electrophysiological techniques, but this specific integration of optogenetics and high-density recording is a novel approach.
Where this research is happening
SEATTLE, UNITED STATES
- ALLEN INSTITUTE — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SVOBODA, KAREL — ALLEN INSTITUTE
- Study coordinator: SVOBODA, KAREL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.