New technology for imaging biomolecules in 3D with high precision
Official title: Next generation biomolecule-retention expansion microscopy for diverse imaging applications
Funded at Carnegie-Mellon University · NIH-11059858 · Data updated 2026-11-12
This study is working on a new way to take super-detailed pictures of tiny molecules in preserved samples, which could help scientists better understand diseases like cancer and brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $535,572 |
| NIH project number | 5R01EB035890-02 |
| Project ID | NIH-11059858 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cancer or neurological disorders who may benefit from advanced imaging techniques.
✕Less likely to help
Patients with conditions that do not involve biomolecular changes detectable by imaging techniques may not receive benefit from this research.
What this research studies
This research focuses on developing a novel imaging technology that allows for the visualization of biomolecules, such as proteins and nucleic acids, in three-dimensional preserved specimens at nanoscale precision. By utilizing a method called expansion microscopy, the researchers aim to enhance the resolution of images obtained from standard light microscopes, enabling a better understanding of cellular organization and disease mechanisms. This approach could significantly improve the ability to detect and analyze changes in biomolecules associated with conditions like cancer and neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding diseases at a molecular level, potentially improving diagnosis and treatment strategies for patients.
How similar studies have gone: Previous research using expansion microscopy has shown promising results, indicating that this approach could be a significant advancement in the field.
Where this research is happening
-
Carnegie-Mellon University
Pittsburgh, United States Active
Researchers
- Principal investigator: Zhao, Yongxin — Carnegie-Mellon University
- Study coordinator: Zhao, Yongxin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.