New technology for analyzing proteins in brain tissues
Spatial proteomics using highly parallel fluorescence hyperspectral and lifetime imaging
This study is testing a new imaging technology that helps scientists look at protein markers in brain tissues more accurately and quickly, which could lead to better understanding and diagnosis of Alzheimer's disease for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10935952 on NIH RePORTER |
What this research studies
This research focuses on developing an innovative technology called Phasor S-FLIM, which allows for the simultaneous and high-precision profiling of protein markers in large brain tissues. By using advanced imaging techniques, this project aims to overcome the limitations of existing methods that are either time-consuming or lack the necessary spatial context. Patients with Alzheimer's disease may benefit from this research as it could lead to better understanding and diagnosis of the disease through improved protein analysis. The approach involves a single round of staining and imaging, making it more efficient and cost-effective for clinical applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnoses of Alzheimer's disease, improving patient care and treatment options.
How similar studies have performed: Other research has shown promise in spatial proteomics, but the Phasor S-FLIM approach is novel and has not been extensively tested in clinical settings.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Kessenbrock, Kai — University of California-Irvine
- Study coordinator: Kessenbrock, Kai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.