New technology for analyzing molecular shapes and dynamics in biological systems
Tractable Tandem Ion Mobility Technology using Structures for Lossless Ion Manipulations and Photodissociation
This study is looking at how to better analyze proteins and carbohydrates in our bodies to help tell the difference between healthy and diseased states, using a new technique that could lead to improved tools for diagnosing various health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project ID | NIH-10754887 on NIH RePORTER |
What this research studies
This research focuses on improving the analysis of proteins, carbohydrates, and other biological molecules by using advanced ion mobility spectrometry (IMS) combined with mass spectrometry (MS). The goal is to enhance our understanding of how the orientation and conformation of these molecules can indicate healthy versus diseased states. By utilizing a novel framework called Structures for Lossless Ion Manipulations (SLIM), the research aims to increase the efficiency and effectiveness of ion separation and analysis. This could lead to better diagnostic tools and insights into various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions that can be characterized by changes in molecular conformation, such as metabolic disorders or certain cancers.
Not a fit: Patients with conditions that do not involve significant molecular changes or those who are not undergoing diagnostic testing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and efficient diagnostic methods for various diseases based on molecular analysis.
How similar studies have performed: Other research has shown promise in using advanced mass spectrometry techniques for molecular analysis, indicating that this approach could be a significant advancement in the field.
Where this research is happening
Pullman, United States
- Washington State University — Pullman, United States (Active)
Researchers
- Principal investigator: Clowers, Brian — Washington State University
- Study coordinator: Clowers, Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.