New targeted therapy for cancer in veterans
Official title: Targeted nanoTherapy to Precision Oncology Platform (TnT POP) for Veterans
Funded at Jesse Brown VA Medical Center · NIH-10922028 · Data updated 2026-11-12
This study is exploring a new way to help veterans who are at higher risk for cancer because of toxin exposure, by using tiny particles that can target cancer cells and change their cholesterol levels to make treatments work better for tough-to-treat cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006541-01 |
| Project ID | NIH-10922028 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with cancers that are resistant to standard treatments.
✕Less likely to help
Patients who do not have cancer or those with cancers that respond well to existing therapies may not benefit from this research.
What this research studies
This research focuses on developing a novel treatment approach for veterans who are at increased risk of cancer due to exposure to toxins. The team has discovered that certain cancers, particularly those resistant to traditional therapies like chemotherapy and radiation, share a common metabolic profile. By using specially engineered nanoparticles that target cancer cells, the research aims to improve treatment outcomes by effectively modulating cholesterol levels in these cells. This innovative approach could lead to more effective therapies for difficult-to-treat cancers.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for veterans suffering from resistant cancers.
How similar studies have gone: While the approach of using engineered nanoparticles for cancer treatment is innovative, similar strategies have shown promise in other research, indicating potential for success.
Where this research is happening
-
Jesse Brown VA Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Thaxton, Colby Shad — Jesse Brown VA Medical Center
- Study coordinator: Thaxton, Colby Shad
Related research
Other NIH-funded projects on the same topics.
-
New ways to stop rheumatoid arthritis damage and relieve pain
Researchers are testing novel targets to prevent the problematic tissue growth in rheumatoid arthritis so people, including veterans, can move more freely and feel better.
-
SHAPE: a wearable shoulder-and-hand device to help after stroke
This project will build and try a wearable device that supports the shoulder and helps move the hand for people with long-standing arm problems after a stroke.
-
SHAPE: a shoulder-and-hand wearable to help people with long-term arm weakness after stroke
This project is building and trying out a wearable device that supports the shoulder and powers the hand to help people with chronic arm weakness after stroke.
-
Prosthetic foot and ankle stiffness for above-knee amputees' walking and standing
This project changes stiffness in prosthetic feet and ankles to find settings that help people with above-knee amputations walk and stand better without making their prosthetic knee unstable.
-
Helping Veterans speak up and make shared decisions about their diabetes care
This project offers a brief video-based program to help Veterans with type 2 diabetes communicate better with their doctors and stick to treatment plans.
-
Do Powered Knee Prostheses Improve Mobility for Transfemoral Amputees
A new powered knee prosthesis with motor-assisted bending and straightening is being tested to see if it improves walking for people who have lost a leg above the knee.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.