New T cell treatments for childhood cancers
Next Generation T cell therapies for childhood cancers (NexTGen)
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10907163
This study is working on new treatments using special immune cells to help kids with solid tumors, like certain types of sarcomas and brain tumors, that current therapies often struggle to treat.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10907163 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced T cell therapies specifically designed for treating solid tumors in children, which current treatments often fail to cure. By utilizing engineered T cells, the project aims to create therapies that can effectively target and combat pediatric solid cancers, overcoming challenges such as tumor heterogeneity and hostile environments. The approach involves detailed studies of primary tumors to identify new targets and understand how the tumor microenvironment affects T cell function, guiding the engineering of more effective T cell therapies. The research is structured into interconnected work packages, initially concentrating on pediatric sarcomas and brain tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with solid tumors, particularly sarcomas and brain tumors, who have not responded to existing treatments.
Not a fit: Patients with hematologic malignancies or those whose tumors do not fall within the targeted categories may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective and less toxic treatments for childhood solid cancers, significantly improving survival rates.
How similar studies have performed: While engineered T cell therapies have shown promise in adult cancers, this approach for pediatric solid tumors is relatively novel and untested.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YARMARKOVICH, MARK — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: YARMARKOVICH, MARK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.