New T cell therapies for childhood cancers
NextGen - CRI
This study is working on new T cell treatments for kids with solid tumors that don't respond well to current therapies, aiming to create options that can better fight cancer while keeping side effects low.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10627010 on NIH RePORTER |
What this research studies
This research focuses on developing advanced T cell therapies specifically for children with solid tumors, which are often resistant to current treatments. By utilizing engineered T cells, the project aims to create therapies that can effectively target and destroy cancer cells while minimizing long-term side effects. The approach involves studying primary tumors to identify new targets and understanding the tumor microenvironment that hinders T cell function. The goal is to make these innovative therapies a standard treatment option for pediatric solid cancers within the next decade.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with solid tumors, particularly sarcomas and brain tumors, who have not responded to conventional therapies.
Not a fit: Patients with hematologic malignancies or those whose tumors do not have suitable targets for T cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide more effective and less toxic treatment options for children suffering from solid tumors.
How similar studies have performed: Other research has shown promising results with engineered T cell therapies in adult cancers, suggesting potential for success in pediatric applications, although this specific approach for solid tumors in children is relatively novel.
Where this research is happening
Washington, United States
- Children's Research Institute — Washington, United States (Active)
Researchers
- Principal investigator: Bollard, Catherine M. — Children's Research Institute
- Study coordinator: Bollard, Catherine M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.