New T cell therapies for childhood cancers
NextGen - CHOP
This study is working on new treatments using specially designed immune cells to help children with tough-to-treat solid tumors, aiming to make these therapies a regular option for them in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10625715 on NIH RePORTER |
What this research studies
This research focuses on developing next-generation T cell therapies specifically for children with solid tumors, which are often resistant to current treatments. The approach involves advanced cellular engineering to create T cells that can effectively target and attack these cancers. By studying primary tumors and understanding the tumor microenvironment, the research aims to identify new targets for therapy and improve T cell function. The goal is to make these engineered therapies a standard treatment option for pediatric solid tumors within the next decade.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with solid tumors, particularly sarcomas and brain tumors.
Not a fit: Patients with hematologic malignancies or those who do not have solid tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide more effective and less toxic treatment options for children suffering from solid cancers.
How similar studies have performed: Previous research has shown promise in using engineered T cell therapies for other types of cancers, indicating potential success for this novel approach in pediatric solid tumors.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Maris, John M — Children's Hosp of Philadelphia
- Study coordinator: Maris, John M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.