New strategies to reduce cocaine cravings and relapse
Cocaine-motivated behaviors: development of novel viral-based strategies to target orexinergic input to the infralimbic cortex.
This study is looking at how a part of the brain that helps control motivation might affect cravings for cocaine, with the goal of finding new ways to help people who are trying to overcome cocaine addiction.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10671018 on NIH RePORTER |
What this research studies
This research investigates how the orexin system in the brain influences motivation and behavior related to cocaine use. By targeting specific genes and pathways in the hypothalamus, the study aims to develop novel viral-based strategies that could help reduce cocaine cravings and prevent relapse. The approach involves studying the effects of manipulating orexin neurons on cocaine-seeking behaviors in animal models, which may provide insights into potential treatments for individuals struggling with cocaine addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cocaine use disorder who are seeking treatment options.
Not a fit: Patients who are not struggling with cocaine addiction or those who have not previously used cocaine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help individuals overcome cocaine addiction and reduce the likelihood of relapse.
How similar studies have performed: Previous research has shown promise in targeting the orexin system for addiction treatment, indicating that this approach may be viable.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Martin-Fardon, Remi — Scripps Research Institute, the
- Study coordinator: Martin-Fardon, Remi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.