New strategies to prevent and treat endometrial cancer
Official title: Route 66 Endometrial Cancer SPORE
Funded at Washington University · NIH-11081476 · Data updated 2026-11-12
This study is looking for new ways to prevent and treat endometrial cancer, especially for women who are dealing with obesity or endometrial hyperplasia, and it offers patients a chance to join clinical trials testing these exciting new therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 23, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $749,771 |
| NIH project number | 3P50CA265793-02S1 |
| Project ID | NIH-11081476 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include women diagnosed with endometrial cancer or those at high risk due to conditions like obesity and endometrial hyperplasia.
✕Less likely to help
Patients with other types of cancer or those not diagnosed with endometrial cancer may not receive benefits from this research.
What this research studies
The Route 66 Endometrial Cancer SPORE focuses on developing and testing innovative approaches to prevent and treat endometrial cancer. It involves collaboration among research teams from multiple institutions to conduct clinical trials and translational research. The program includes projects aimed at improving treatment responses and prevention strategies, particularly for women with obesity and endometrial hyperplasia. Patients may have the opportunity to participate in clinical trials that explore new therapies and prevention methods.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and prevention strategies for endometrial cancer, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in similar approaches to cancer treatment and prevention, indicating potential for success in this area.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Mutch, David G — Washington University
- Study coordinator: Mutch, David G
Related research
Other NIH-funded projects on the same topics.
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Prognostic tools to guide adjuvant therapy for Black women after hysterectomy for endometrial cancer
A new project aims to create and validate easy-to-use tools that help doctors tailor post-surgery treatment for Black women with endometrial cancer.
-
Understanding why guideline-concordant endometrial cancer treatment varies in high-risk groups
This project looks at why some patients with endometrial cancer don’t receive care that follows national guidelines, aiming to find ways to ensure more patients get the best-supported treatments.
-
Targeting hormone resistance to prevent endometrial cancer
Aims to boost progesterone’s cancer-preventing effect in the lining of the uterus to stop cancer from developing in people at risk, especially those who are obese or young.
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Inhibiting AXL to Improve Treatment Response in Endometrial Cancer
A cancer treatment study is testing whether blocking AXL with batiraxcept together with standard chemotherapy can help people with certain aggressive uterine cancers respond better.
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Targeting HSPA Proteins to Help Women with Advanced or Recurrent Endometrial Cancer
Aims to test a drug called SHetA2 that may slow or stop growth of advanced endometrial cancer by targeting cancer-friendlier proteins, with a focus on reducing treatment toxicity.
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Endometrial Cancer SPORE: New strategies to prevent and treat endometrial cancer
A multi-institution program is testing new ways to prevent and treat endometrial cancer in people, with three linked projects and multiple cores to support translational research.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.