New small molecules to improve heart failure treatment
Official title: P7C3 based small molecule for Heart failure treatment
Funded at University of South Florida · NIH-10891927 · Data updated 2026-11-12
This study is looking at a new type of medicine that could help boost energy levels in heart failure patients by increasing a key molecule called NAD+, which might improve heart function and tackle the root causes of the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 5, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $517,475 |
| NIH project number | 1R61HL170457-01A1 |
| Project ID | NIH-10891927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure who may benefit from new therapeutic approaches targeting NAD+ levels.
✕Less likely to help
Patients with heart failure who have contraindications to experimental therapies or those who are not responsive to NAD+ modulation may not benefit from this research.
What this research studies
This research investigates the potential of a new class of small molecules, specifically P7C3-based compounds, to enhance the levels of NAD+, a crucial molecule for cellular energy and repair, in patients with heart failure. The approach involves using advanced medicinal chemistry and 3D structural analysis to design and test these compounds in laboratory models. The research aims to identify effective molecules that can restore NAD+ levels and improve heart function, moving from initial in vitro testing to more complex ex vivo and in vivo studies. If successful, this could lead to new therapies that address the underlying causes of heart failure rather than just managing symptoms.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option that improves heart function and quality of life for patients with heart failure.
How similar studies have gone: Previous research has shown promise in using NAD+ precursors and modulators for improving heart function, indicating that this approach has potential based on existing findings.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Tipparaju, Srinivas M. — University of South Florida
- Study coordinator: Tipparaju, Srinivas M.
Related research
Other NIH-funded projects on the same topics.
-
AI-supported heart failure diagnosis and management in Rwanda
Aiming to help people with suspected heart failure in Rwanda get faster, more accurate diagnoses and better care using AI-guided ultrasound and care protocols.
-
AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
An NIH-funded project will test whether AI-enhanced, easy-to-use heart ultrasound can help non-experts diagnose and manage heart failure in Rwanda.
-
HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
-
Triple gene therapy approach to heal the heart after a heart attack
A new therapy combines three genetic approaches delivered by a virus to help the heart heal after a heart attack.
-
Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
-
Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.