New small molecules to improve heart failure treatment
P7C3 based small molecule for Heart failure treatment
This study is looking at a new type of medicine that could help boost energy levels in heart failure patients by increasing a key molecule called NAD+, which might improve heart function and tackle the root causes of the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10891927 on NIH RePORTER |
What this research studies
This research investigates the potential of a new class of small molecules, specifically P7C3-based compounds, to enhance the levels of NAD+, a crucial molecule for cellular energy and repair, in patients with heart failure. The approach involves using advanced medicinal chemistry and 3D structural analysis to design and test these compounds in laboratory models. The research aims to identify effective molecules that can restore NAD+ levels and improve heart function, moving from initial in vitro testing to more complex ex vivo and in vivo studies. If successful, this could lead to new therapies that address the underlying causes of heart failure rather than just managing symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure who may benefit from new therapeutic approaches targeting NAD+ levels.
Not a fit: Patients with heart failure who have contraindications to experimental therapies or those who are not responsive to NAD+ modulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option that improves heart function and quality of life for patients with heart failure.
How similar studies have performed: Previous research has shown promise in using NAD+ precursors and modulators for improving heart function, indicating that this approach has potential based on existing findings.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Tipparaju, Srinivas M. — University of South Florida
- Study coordinator: Tipparaju, Srinivas M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.