New small molecule to enhance dental implant integration with bone
Official title: Novel Small Molecule for Improved Dental Implant Osseointegration
Funded at Cayman Chemical Company, INC. · NIH-10489776 · Data updated 2026-11-12
This study is testing a new medicine that could help people with weak bones, like those with osteoporosis, get dental implants that fit better and last longer.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cayman Chemical Company, INC. NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 16, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $906,661 |
| NIH project number | 5R44DE030370-02 |
| Project ID | NIH-10489776 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with missing teeth who have low bone density or osteoporosis and are considering dental implants.
✕Less likely to help
Patients with healthy bone density and no history of dental implant failure are unlikely to benefit from this research.
What this research studies
This research investigates a novel small molecule designed to improve the integration of dental implants into the jawbone, particularly for patients with bone density issues like osteoporosis. The approach involves using a specific compound that has shown promise in laboratory settings for promoting bone regeneration and enhancing the mechanical stability of implants. By focusing on patients who may struggle with traditional implants due to bone density challenges, this research aims to provide a more effective solution for dental restoration. The study will involve both laboratory testing and clinical trials to assess the efficacy of the compound in human subjects.
Why it matters
Potential benefit: If successful, this research could lead to improved dental implant outcomes for patients with compromised bone density, reducing the risk of implant failure.
How similar studies have gone: Previous research has shown success with similar approaches in enhancing bone regeneration, making this a promising area of investigation.
Where this research is happening
-
Cayman Chemical Company, INC.
Ann Arbor, United States Active
Researchers
- Principal investigator: Morano, Maria Ines — Cayman Chemical Company, INC.
- Study coordinator: Morano, Maria Ines
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.