New Nanoparticle Therapy for Pancreatic Cancer
Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer
This project develops tiny particles to deliver medicine and boost the immune system against pancreatic cancer, making treatments more effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11110491 on NIH RePORTER |
What this research studies
Pancreatic cancer is very challenging to treat because a dense barrier around the tumor blocks medicines and immune cells from reaching it. This project creates special nanoparticles designed to break through this barrier and carry chemotherapy drugs directly to the cancer cells. These nanoparticles also help activate the body's immune system to fight the tumor more effectively, especially when combined with existing immune-boosting therapies. The goal is to improve how well treatments work and overcome the cancer's resistance.
Who could benefit from this research
Good fit: This foundational research is for patients with pancreatic cancer who may benefit from future therapies that overcome drug resistance and boost immune responses.
Not a fit: Patients without pancreatic cancer or those not seeking advanced therapeutic options would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this approach could lead to more effective treatments for pancreatic cancer by improving drug delivery and enhancing the body's immune response against tumors.
How similar studies have performed: While immune checkpoint therapies have shown success in other cancers, pancreatic cancer has responded poorly, making this novel approach to overcome resistance particularly important.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Yang, Lily — Emory University
- Study coordinator: Yang, Lily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.