New Nanobodies for HIV Treatment
Development of Broadly Neutralizing Nanobodies for Advancing AIDS Therapy
This research aims to create tiny, powerful antibodies called nanobodies to better fight the Human Immunodeficiency Virus (HIV) for people living with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11159830 on NIH RePORTER |
What this research studies
HIV continues to be a major health challenge worldwide, even with current treatments. This project explores a new approach using nanobodies, which are smaller and may work more effectively than traditional antibodies. We are working to find and design these nanobodies to target multiple parts of the HIV virus, making them more potent against different strains. Our goal is to develop treatments that are both more effective and easier to use for patients.
Who could benefit from this research
Good fit: This foundational research is for individuals living with HIV who may benefit from future advanced therapies.
Not a fit: Patients who do not have HIV would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new, more effective, and simpler treatments for people living with HIV, potentially overcoming current challenges like drug resistance.
How similar studies have performed: While traditional antibodies have shown promise against HIV, this approach with engineered nanobodies targeting multiple sites is a novel strategy building on existing knowledge.
Where this research is happening
Atlanta, United States
- Georgia State University — Atlanta, United States (Active)
Researchers
- Principal investigator: Xu, Jianliang — Georgia State University
- Study coordinator: Xu, Jianliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.