New multi-stage malaria medicines
Official title: Novel Multiple-Stage Active Antimalarials
Funded at Portland State University · NIH-11227707 · Data updated 2026-11-12
Developing oral drugs that attack malaria at several stages to help people, including children, and to work against drug-resistant parasites.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland State University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 14, 2019 |
| Project end | August 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $681,816 |
| NIH project number | 2R01AI141972-06 |
| Project ID | NIH-11227707 on NIH RePORTER |
Who could benefit from this research
✓Could help
People at risk of or currently infected with malaria in endemic areas, including children, especially those with infections resistant to existing medicines, would be the eventual candidates for clinical trials.
✕Less likely to help
People without malaria or whose infections respond well to current, effective treatments are unlikely to benefit immediately from this preclinical work.
What this research studies
You are being told about efforts to turn promising tambjamine-based compounds into medicines that can be taken by mouth. Researchers are changing the chemistry to improve how the drugs are absorbed, how long they last in the body, and how well they clear infection. They are testing the candidates in animal models to measure cure rates, safety, and metabolic stability. The goal is to produce a lead drug ready for future human clinical testing.
Why it matters
Potential benefit: If successful, this work could produce affordable, well-tolerated oral treatments that cure malaria and work against strains resistant to current drugs.
How similar studies have gone: Related tambjamine lead compounds have shown strong oral curative activity and good safety in animal models, but human efficacy has not yet been demonstrated.
Where this research is happening
-
Portland State University
Portland, United States Active
Researchers
- Principal investigator: Kancharla, Papireddy — Portland State University
- Study coordinator: Kancharla, Papireddy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.