New multi-stage malaria medicines
Novel Multiple-Stage Active Antimalarials
['FUNDING_R01'] · PORTLAND STATE UNIVERSITY · NIH-11227707
Developing oral drugs that attack malaria at several stages to help people, including children, and to work against drug-resistant parasites.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PORTLAND STATE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11227707 on ClinicalTrials.gov |
What this research studies
You are being told about efforts to turn promising tambjamine-based compounds into medicines that can be taken by mouth. Researchers are changing the chemistry to improve how the drugs are absorbed, how long they last in the body, and how well they clear infection. They are testing the candidates in animal models to measure cure rates, safety, and metabolic stability. The goal is to produce a lead drug ready for future human clinical testing.
Who could benefit from this research
Good fit: People at risk of or currently infected with malaria in endemic areas, including children, especially those with infections resistant to existing medicines, would be the eventual candidates for clinical trials.
Not a fit: People without malaria or whose infections respond well to current, effective treatments are unlikely to benefit immediately from this preclinical work.
Why it matters
Potential benefit: If successful, this work could produce affordable, well-tolerated oral treatments that cure malaria and work against strains resistant to current drugs.
How similar studies have performed: Related tambjamine lead compounds have shown strong oral curative activity and good safety in animal models, but human efficacy has not yet been demonstrated.
Where this research is happening
PORTLAND, UNITED STATES
- PORTLAND STATE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KANCHARLA, PAPIREDDY — PORTLAND STATE UNIVERSITY
- Study coordinator: KANCHARLA, PAPIREDDY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.