New mRNA Vaccines for Tuberculosis
Official title: Development of Novel mRNA Vaccines Against Mycobacterium tuberculosis
Funded at International AIDS Vaccine Initiative · NIH-11325903 · Data updated 2026-11-12
This research explores new mRNA vaccine technology to protect adolescents and adults from tuberculosis, a serious lung infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | International AIDS Vaccine Initiative NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 20, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $700,469 |
| NIH project number | 4R33AI169132-04 |
| Project ID | NIH-11325903 on NIH RePORTER |
Who could benefit from this research
✓Could help
This preclinical research is focused on developing a vaccine that would ultimately benefit adolescents and adults, including those living with conditions like HIV that increase TB risk.
✕Less likely to help
Patients will not receive direct benefit from this early-stage laboratory and animal model research, as it is not yet ready for human testing.
What this research studies
Tuberculosis (TB) remains a major global health challenge, causing millions of illnesses and deaths each year, especially with the rise of drug-resistant forms and its connection to HIV. Current vaccine efforts often use similar approaches, so this project aims to bring fresh ideas and new technology to the field. Researchers are using advanced mRNA vaccine methods, similar to those used for COVID-19, to create a more diverse and effective vaccine. The goal is to develop a powerful new tool that could prevent people from getting, developing, and spreading TB.
Why it matters
Potential benefit: If successful, this work could lead to a highly effective vaccine that prevents tuberculosis, including drug-resistant forms, and significantly reduces its global impact.
How similar studies have gone: While other TB vaccine candidates are in development, this project introduces novel mRNA technology and aims to broaden the range of immune responses, offering a new approach.
Where this research is happening
-
International AIDS Vaccine Initiative
New York, United States Active
Researchers
- Principal investigator: Postler, Thomas Siegmund — International AIDS Vaccine Initiative
- Study coordinator: Postler, Thomas Siegmund
Related research
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-
Pulmonary rehabilitation to reduce breathing problems after tuberculosis
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-
Pulmonary rehab to reduce breathing troubles after TB
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-
Air pollution and tuberculosis spread in Kampala, Uganda
This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.
-
Air pollution and TB spread in Ugandan urban slums
This project explores whether exposure to air pollution makes tuberculosis more likely to spread within households in a crowded Ugandan slum.
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Air pollution and TB transmission in Kampala’s urban slums
This project looks at whether air pollution from PM2.5 makes tuberculosis spread more easily from infected people to their neighbors in urban slums of Kampala, Uganda.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.