New microscopes to improve 3D imaging of living tissues
Transformative microscopes to image across spatiotemporal scales
This study is working on new ways to take super-detailed pictures of living cells in larger samples, like whole organisms, to help us better understand how cells work together in real life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10841330 on NIH RePORTER |
What this research studies
This research focuses on developing advanced microscopy techniques to better visualize the organization and activity of cells within living tissues. By enhancing light-sheet fluorescence microscopy (LSFM) with super-resolution methods, the project aims to achieve high-resolution imaging of cellular dynamics in larger samples, such as entire model organisms. The approach includes innovative sampling strategies to autonomously explore large samples while maintaining high detail in specific areas of interest. This could lead to significant advancements in our understanding of biological processes at the molecular level.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions that involve complex cellular dynamics, such as cancer or developmental disorders.
Not a fit: Patients with conditions that do not involve cellular imaging or tissue organization may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide unprecedented insights into cellular behavior and tissue organization, potentially leading to breakthroughs in biomedical research and treatment strategies.
How similar studies have performed: Other research has shown success in enhancing imaging techniques, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Fiolka, Reto Paul — Ut Southwestern Medical Center
- Study coordinator: Fiolka, Reto Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.