New microscope lenses to improve 3D imaging of cells
Official title: High-resolution extended-depth phase-engineered objectives to accelerate spatial 'omics R&D through computational optics
Funded at Double Helix Optics INC. · NIH-11068713 · Data updated 2026-11-12
This study is working on new microscope lenses that help scientists take clearer 3D pictures of living cells more quickly and gently, making it easier to see how cells work in real-time.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Double Helix Optics INC. NIH-funded |
| Lab location | 1 site (Boulder, United States) |
| Project start | September 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,084,722 |
| NIH project number | 2R44GM151926-02 |
| Project ID | NIH-11068713 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that require detailed cellular analysis, such as cancer or neurodegenerative diseases.
✕Less likely to help
Patients with conditions that do not involve cellular imaging or spatial omics may not benefit from this research.
What this research studies
This research focuses on developing advanced microscope lenses that enhance the ability to capture detailed 3D images of cells. By using engineered point spread function (ePSF) technology, these lenses will allow for faster imaging with less damage to live cells, making it easier to observe cellular processes in real-time. The project aims to create two types of lenses that will improve depth of field and spatial information capture without compromising image quality. This innovative approach could significantly accelerate research in spatial omics, which studies the spatial organization of cellular components.
Why it matters
Potential benefit: If successful, this research could lead to more efficient and accurate methods for studying cellular behavior and disease mechanisms.
How similar studies have gone: Previous research in optical microscopy has shown promise in enhancing imaging techniques, suggesting that this approach could also yield significant advancements.
Where this research is happening
-
Double Helix Optics INC.
Boulder, United States Active
Researchers
- Principal investigator: Gaumer, Scott — Double Helix Optics INC.
- Study coordinator: Gaumer, Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.