New methods to repair spina bifida before birth
Biomimetic intervention strategies for endogenous in utero repair of Spina Bifida
This study is looking at new ways to help fix spina bifida before a baby is born by using special techniques and cells from the amniotic fluid, aiming to make the treatment less invasive and more effective for families facing this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11180276 on NIH RePORTER |
What this research studies
This research focuses on developing innovative strategies to repair spina bifida in utero, which is a serious birth defect affecting the spinal cord. By utilizing bioengineering techniques and stem cells derived from amniotic fluid, the project aims to create a healing environment that can stimulate the body's natural repair processes. The approach seeks to minimize the invasiveness of current surgical methods by exploring less invasive interventions that can be applied during pregnancy. The research will involve testing the effectiveness of these new strategies in a controlled setting to assess their potential impact on reducing the severity of spina bifida lesions.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals whose fetuses are diagnosed with spina bifida.
Not a fit: Patients who have already delivered or those whose fetuses do not have spina bifida may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for spina bifida, improving outcomes for affected infants.
How similar studies have performed: Previous research has shown promise in using similar bioengineering and stem cell approaches for treating other conditions, indicating potential for success in this novel application.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Corradetti, Bruna — Baylor College of Medicine
- Study coordinator: Corradetti, Bruna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.