New methods to reduce inflammation in the brain for people with demyelinating diseases.
New Approaches to Combat CNS Inflammation: Targeting a Metabolic Enzyme in Demyelinating Disease
This study is looking at how a certain enzyme called DGAT1 affects inflammation in the brain and spinal cord for people with multiple sclerosis, with the hope of finding new treatment options that could help patients, especially those in high-risk groups like military personnel.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Admin Palo Alto Health Care Sys NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project ID | NIH-11003741 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific metabolic enzyme, diacylglycerol O-acyltransferase-1 (DGAT1), affects inflammation in the central nervous system (CNS) related to multiple sclerosis (MS). By studying animal models that mimic MS, the research aims to uncover how DGAT1 influences the behavior of immune cells that contribute to CNS damage. The goal is to identify new therapeutic strategies that could lead to better treatment options for patients suffering from MS, especially those in high-risk groups like military personnel.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with multiple sclerosis, particularly those with a history of autoimmune conditions.
Not a fit: Patients with non-autoimmune neurological disorders or those without a diagnosis of multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that more effectively manage or reduce the symptoms of multiple sclerosis.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways to influence immune responses in autoimmune diseases, suggesting potential for success in this approach.
Where this research is happening
Palo Alto, United States
- Veterans Admin Palo Alto Health Care Sys — Palo Alto, United States (Active)
Researchers
- Principal investigator: Zabel, Brian a. — Veterans Admin Palo Alto Health Care Sys
- Study coordinator: Zabel, Brian a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.