New methods to prevent Lyme disease by targeting its animal hosts
Efficacy of novel reservoir-host targeted bait formulations against a tick-borne pathogen
This study is testing new bait that could help stop the spread of Lyme disease by targeting the animals that ticks rely on, and it's designed for anyone interested in finding better ways to control this illness in nature.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10904990 on NIH RePORTER |
What this research studies
This research investigates innovative bait formulations designed to target the animal hosts of the Lyme disease-causing bacteria, Borrelia burgdorferi. By using genetically modified strains of the bacteria that produce specific lipoproteins, the study aims to create a method that interrupts the transmission cycle of Lyme disease between ticks and their vertebrate hosts. The approach involves testing these bait formulations in mouse models to evaluate their effectiveness in preventing infection. If successful, this research could lead to new strategies for controlling Lyme disease in the environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in areas where Lyme disease is prevalent and who may be at risk of tick exposure.
Not a fit: Patients who have already been diagnosed with Lyme disease and are seeking treatment for existing infections may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel way to reduce the incidence of Lyme disease by disrupting its transmission cycle.
How similar studies have performed: While the approach of using targeted bait formulations is innovative, similar strategies in other contexts have shown promise in controlling vector-borne diseases.
Where this research is happening
San Antonio, United States
- University of Texas San Antonio — San Antonio, United States (Active)
Researchers
- Principal investigator: Seshu, Janakiram — University of Texas San Antonio
- Study coordinator: Seshu, Janakiram
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.