New methods to prevent infections after joint replacement surgeries
Synergistic anti-fouling coating and minimal systemic antibiotic injections for combating periprosthetic infections
This study is looking at a new way to help prevent infections after joint replacement surgeries by using a special coating on implants along with a small amount of antibiotics, which could lead to better recovery and fewer infections for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11087644 on NIH RePORTER |
What this research studies
This research investigates innovative ways to prevent periprosthetic infections, which can occur after joint replacement surgeries. It focuses on using a special anti-fouling coating on implants combined with a minimal dose of antibiotics to effectively combat bacteria that form biofilms on these surfaces. The approach aims to enhance the effectiveness of current treatments by engineering a robust coating that can be applied to metallic implants, providing sustained protection against harmful bacteria during surgeries. Patients may benefit from improved outcomes and reduced risk of infections associated with joint replacements.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals scheduled for primary or revision joint replacement surgeries who are at risk for periprosthetic infections.
Not a fit: Patients who have already undergone joint replacement surgeries without complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of infections following joint replacement surgeries, leading to better recovery and health outcomes for patients.
How similar studies have performed: Previous research has shown promising results with similar anti-fouling strategies and antibiotic combinations, indicating potential for success in this novel approach.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Song, Jie — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Song, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.