New methods to prevent and treat bladder damage from radiation therapy
Novel Mechanistic Approaches in Prevention, Treatment and Non-Invasive Assessment of Radiation Cystitis in Mice
This study is looking at how radiation therapy can impact the bladder and cause a condition called radiation cystitis, and it's for people who have had treatment for pelvic cancers; researchers are using mice to find ways to prevent and treat this issue and to create easier ways to check on bladder health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10838465 on NIH RePORTER |
What this research studies
This research investigates how radiation therapy affects the bladder, particularly focusing on a condition called radiation cystitis that can occur after treatment for pelvic cancers. Using mouse models, the researchers will explore the mechanisms behind this condition and test new approaches to prevent and treat it, as well as develop non-invasive methods to monitor bladder health. The study aims to improve understanding of bladder damage and find better therapeutic options for patients undergoing radiation therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing radiation therapy for pelvic cancers who may be at risk for developing radiation cystitis.
Not a fit: Patients who have not received radiation therapy or those with non-pelvic cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bladder damage caused by radiation therapy, enhancing the quality of life for cancer patients.
How similar studies have performed: While there have been studies on radiation cystitis, this research aims to explore novel mechanistic approaches, making it a potentially groundbreaking effort in this area.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Kanai, Anthony John — University of Pittsburgh at Pittsburgh
- Study coordinator: Kanai, Anthony John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.