New methods to predict heart problems related to aortic disease
Official title: Novel molecular and cardiac imaging paradigms for precision medicine in aortopathy
Funded at Indiana University Indianapolis · NIH-10991323 · Data updated 2026-11-12
This study is looking at thoracic aortic aneurysm (TAA) to find new ways to understand how it develops and affects people, so that doctors can create more personalized treatment plans for both kids and adults with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $624,724 |
| NIH project number | 5R01HL171631-02 |
| Project ID | NIH-10991323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adults diagnosed with thoracic aortic aneurysm who are receiving ongoing cardiac care.
✕Less likely to help
Patients without a diagnosis of thoracic aortic aneurysm or those not receiving cardiac care may not benefit from this research.
What this research studies
This research focuses on thoracic aortic aneurysm (TAA), a condition that can lead to serious heart issues in both children and adults. The project aims to develop innovative techniques using genetic analysis and cardiac imaging to better understand and predict how this disease progresses over time. By identifying specific genetic markers associated with TAA, the researchers hope to create personalized risk assessments for patients, allowing for more tailored and effective treatment plans. Participants will be enrolled from specialized pediatric cardiac centers, where they will undergo genetic testing and imaging assessments.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of disease progression in patients with aortic disease, improving their long-term care and outcomes.
How similar studies have gone: Previous research has shown promise in using genetic markers to predict disease progression in other cardiovascular conditions, suggesting potential success for this novel approach.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Landis, Benjamin John — Indiana University Indianapolis
- Study coordinator: Landis, Benjamin John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.