New methods to modify important drug components for better medicines
Official title: Selective Methods to Transform Pyridines and Diazines that Facilitate Medicinal Chemistry
Funded at Colorado State University · NIH-11011756 · Data updated 2026-11-12
This study is looking at new ways to change certain chemical compounds found in medicines to make them work better, which could lead to improved treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | April 21, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $259,966 |
| NIH project number | 1R35GM156435-01 |
| Project ID | NIH-11011756 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals with conditions that could be treated by new drugs developed from modified pyridine and diazine compounds.
✕Less likely to help
Patients with conditions that do not involve the use of pyridine or diazine-based medications may not receive any benefit from this research.
What this research studies
This research focuses on developing innovative techniques to modify pyridine and diazine compounds, which are commonly found in FDA-approved drugs. By creating new synthetic strategies, the project aims to enhance the interaction of these compounds with biological targets, potentially leading to more effective medications. The research will explore various chemical processes to selectively add functional groups to these heterocycles, which can improve their performance in drug discovery. Patients may benefit from advancements in drug formulations that arise from these new methods.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and targeted medications for various health conditions.
How similar studies have gone: Previous research has shown promise in modifying heterocycles for drug development, indicating that this approach could yield significant advancements.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Mcnally, Andrew — Colorado State University
- Study coordinator: Mcnally, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.