New methods to measure the impact of typhoid vaccines
Novel tools for measuring typhoid vaccine impact
This study is looking at new ways to see how well typhoid vaccines work, especially in places with fewer resources, by testing methods like checking blood samples, looking for viruses in wastewater, and tracking how typhoid spreads, all to help improve health responses for people affected by this disease in Vellore, India.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11082520 on NIH RePORTER |
What this research studies
This research investigates innovative tools to assess the effectiveness of typhoid vaccines, particularly in low-resource settings. It involves a large trial in Vellore, India, where researchers will test three new methods: analyzing blood samples for immune responses, detecting specific viruses in wastewater, and using genetic tracking to understand how typhoid spreads. By improving the measurement of typhoid incidence, this project aims to enhance public health responses to this serious disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults living in areas with high rates of typhoid fever, particularly in low- and middle-income countries.
Not a fit: Patients living in regions with low or no incidence of typhoid fever may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and control of typhoid fever, ultimately reducing illness and death rates in vulnerable populations.
How similar studies have performed: Previous research has shown promise in using innovative surveillance methods for infectious diseases, suggesting potential success for this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Andrews, Jason Randolph — Stanford University
- Study coordinator: Andrews, Jason Randolph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.