New methods to measure T-cell activity in cancer treatment
New tools for quantitative non-invasive recording of biochemical signals
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11005306
This study is looking for new ways to safely track how T-cells, which are important for fighting cancer, respond to tumors over time, with the hope of improving CAR T-cell therapy for patients with solid tumors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11005306 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative tools to non-invasively record biochemical signals related to T-cell function, particularly in the context of cancer therapy. By tracking calcium signaling in T-cells, the study aims to understand how these immune cells respond to tumors over time. This approach could help identify T-cells that are effective against cancer and those that may become exhausted. The goal is to enhance the effectiveness of CAR T-cell therapy, especially for solid tumors, by providing insights into T-cell behavior in the tumor microenvironment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with blood cancers or solid tumors who are undergoing or considering CAR T-cell therapy.
Not a fit: Patients with conditions unrelated to T-cell function or those not receiving cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved CAR T-cell therapies that are more effective in treating various cancers.
How similar studies have performed: Previous research has shown promise in using calcium signaling as a measure of T-cell function, indicating that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHANER, NATHAN CHRISTOPHER — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: SHANER, NATHAN CHRISTOPHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy