New methods to measure protein structures and their functions
Innovative Native Ion Mobility Approaches for Transformational Measurements in Structural Biology
This study is exploring new ways to look at how proteins change shape and work with other molecules, which could help us understand diseases caused by protein problems, like amyloidosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-10689746 on NIH RePORTER |
What this research studies
This research focuses on developing innovative techniques to better understand protein structures and their dynamics, particularly how proteins fold and interact with other molecules. By utilizing advanced mass spectrometry and ion mobility methods, the project aims to capture detailed snapshots of proteins in various states, including their non-native forms. This approach could provide critical insights into how proteins function in biological processes, which is essential for understanding diseases related to protein misfolding, such as amyloidosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by amyloid diseases or other conditions related to protein misfolding.
Not a fit: Patients with conditions unrelated to protein structure or function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating diseases caused by protein misfolding.
How similar studies have performed: Previous research using mass spectrometry and ion mobility techniques has shown promise in understanding protein structures, indicating that this approach could yield valuable results.
Where this research is happening
College Station, United States
- Texas A&m University — College Station, United States (Active)
Researchers
- Principal investigator: Russell, David H — Texas A&m University
- Study coordinator: Russell, David H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.