New methods to improve care for obstructive sleep apnea
Official title: Developing a P4 Medicine Approach to Obstructive Sleep Apnea
Funded at University of Pennsylvania · NIH-10880308 · Data updated 2026-11-12
This study is looking to improve care for people with obstructive sleep apnea by finding out how genetics and other biological factors play a role, so that we can create personalized treatment plans just for you.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,292,560 |
| NIH project number | 5P01HL160471-02 |
| Project ID | NIH-10880308 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with obstructive sleep apnea, particularly those with varying genetic backgrounds and phenotypes.
✕Less likely to help
Patients without a diagnosis of obstructive sleep apnea or those who do not have genetic factors contributing to the condition may not benefit from this research.
What this research studies
This research focuses on enhancing the care of obstructive sleep apnea (OSA) through a personalized medicine approach. It aims to identify genetic factors and biomarkers that contribute to OSA, utilizing advanced imaging techniques and machine learning to analyze data from patients. By understanding the genetic and biological underpinnings of OSA, the research seeks to develop tailored prevention and treatment strategies for individuals affected by this condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients with obstructive sleep apnea.
How similar studies have gone: Previous research has shown promise in using genetic and biomarker approaches to understand and treat obstructive sleep apnea, indicating that this research builds on established methodologies.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Pack, Allan I — University of Pennsylvania
- Study coordinator: Pack, Allan I
Related research
Other NIH-funded projects on the same topics.
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A study at the University of Pennsylvania will look for microRNA signs in the blood that reflect how bad sleep apnea is and how well CPAP therapy works for patients.
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Personalized sleep apnea care using genetics and biomarkers
A patient-friendly look at a research program aiming to tailor sleep apnea care using genetics, biomarkers, and brain/body signals to improve prediction and prevention.
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Night-to-night sleep-disordered breathing differences in women and men
A study to find better biomarkers for sleep apnea severity, especially in women, by monitoring people at home for a week and tracking daily mood and energy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.