New methods to identify DNA and RNA changes using advanced sequencing technology
Official title: Novel bioinformatics methods to detect DNA and RNA modifications using Nanopore long-read sequencing
Funded at Children's Hosp of Philadelphia · NIH-10933502 · Data updated 2026-11-12
This study is working on new ways to look at DNA and RNA changes that can help us understand how genes work and how they relate to diseases, using advanced technology to get clearer results, which could lead to better insights into different health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 22, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $690,069 |
| NIH project number | 5R01HG013359-02 |
| Project ID | NIH-10933502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic conditions or cancers where DNA and RNA modifications play a significant role.
✕Less likely to help
Patients without genetic disorders or those not affected by conditions related to DNA and RNA modifications may not benefit from this research.
What this research studies
This research focuses on developing innovative bioinformatics techniques to detect modifications in DNA and RNA that are crucial for understanding gene regulation and diseases. By utilizing advanced long-read sequencing technology, the project aims to overcome limitations of traditional methods that often provide indirect results and are unable to analyze repetitive regions of the genome. The researchers will create tools that can analyze the raw data generated from sequencing to identify both common and rare modifications, potentially leading to better insights into various health conditions.
Why it matters
Potential benefit: If successful, this research could enhance the understanding of genetic modifications linked to diseases, leading to improved diagnostic and therapeutic strategies for patients.
How similar studies have gone: Previous research has shown promise in using advanced sequencing technologies for detecting genetic modifications, indicating that this approach has the potential for success.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Wang, Kai — Children's Hosp of Philadelphia
- Study coordinator: Wang, Kai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.