New methods to identify cell types in Alzheimer's brains
Novel in situ proteomics methods to classify cell types in Alzheimer’s brains - Administrative Supplement
This study is working on new ways to look at proteins in brain cells from people with Alzheimer's disease, which could help doctors better understand the condition and find improved ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10577542 on NIH RePORTER |
What this research studies
This research aims to develop advanced techniques for analyzing proteins in individual cells within preserved brain tissues, particularly focusing on Alzheimer's disease. By creating highly sensitive and multiplexed probes, the project seeks to improve the classification of various cell types in the brain, which could enhance our understanding of neurodegenerative diseases. The approach involves profiling proteins in formalin-fixed paraffin-embedded tissues, which are commonly used in clinical settings. If successful, these methods could lead to better diagnostic and treatment options for Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other types of neurodegenerative diseases that are not Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using advanced protein profiling techniques, indicating that this approach could yield significant insights.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Guo, Jia — Arizona State University-Tempe Campus
- Study coordinator: Guo, Jia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.