New methods to evaluate the effectiveness of vaccines against infectious diseases
Emerging methods and applications for test-negative studies of of infectious disease interventions
This study is looking at how well vaccines work against infections like pneumococcal pneumonia and rotavirus by comparing people who have symptoms and get tested, so we can find better ways to understand vaccine protection in different countries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10661722 on NIH RePORTER |
What this research studies
This research focuses on improving the evaluation of vaccine effectiveness for infectious diseases using a method called test-negative design (TND). By enrolling individuals who seek care for symptoms and testing them for specific pathogens, researchers can compare those who test positive and negative to assess vaccine performance. The study aims to develop new strategies to measure how well vaccines protect against infections and the progression of those infections into diseases. It will specifically look at vaccines for pneumococcal pneumonia and rotavirus across different income countries.
Who could benefit from this research
Good fit: Ideal candidates for this research include children aged 0-21 who are experiencing symptoms of infectious diseases.
Not a fit: Patients who are not experiencing symptoms of infectious diseases or are outside the age range of 0-21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and improved effectiveness of vaccines, ultimately enhancing public health outcomes.
How similar studies have performed: Previous research using test-negative designs has shown promise in evaluating vaccine effectiveness, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Jewell, Nicholas P — University of California Berkeley
- Study coordinator: Jewell, Nicholas P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.