New methods to analyze preserved tissue samples for disease insights
Official title: Scalable and quantitative chromatin profiling from formalin-fixed paraffin-embedded samples
Funded at Epicypher, INC. · NIH-11004854 · Data updated 2026-11-12
This study is working on new ways to look at DNA features in preserved tissue samples to help find important clues for better understanding diseases and discovering new treatments, making it easier for doctors to help patients like you.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Epicypher, INC. NIH-funded |
| Lab location | 1 site (Research Triangle Park, UNITED STATES) |
| Project start | May 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,024,448 |
| NIH project number | 2R44HG013071-02 |
| Project ID | NIH-11004854 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with preserved tissue samples from various diseases, particularly those stored in FFPE format.
✕Less likely to help
Patients without access to FFPE tissue samples or those whose conditions do not involve chromatin-related abnormalities may not benefit from this research.
What this research studies
This research focuses on developing advanced techniques to analyze chromatin features in formalin-fixed paraffin-embedded (FFPE) tissue samples, which are commonly used in clinical settings. By improving the sensitivity and resolution of chromatin profiling, the project aims to unlock valuable epigenetic information that could lead to the discovery of new biomarkers and therapeutic targets. The methodology involves creating a next-generation assay that can effectively work with the DNA from these preserved samples, which has been challenging due to damage incurred during the preservation process. This innovative approach could significantly enhance our understanding of diseases at the molecular level.
Why it matters
Potential benefit: If successful, this research could provide new insights into disease mechanisms and lead to the development of novel diagnostic and therapeutic strategies.
How similar studies have gone: Other research has shown promise in developing chromatin profiling techniques, but this specific approach targeting FFPE samples is relatively novel.
Where this research is happening
-
Epicypher, INC.
Research Triangle Park, United States Active
Researchers
- Principal investigator: Keogh, Michael-Christopher — Epicypher, INC.
- Study coordinator: Keogh, Michael-Christopher
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.