New methods to analyze genetics of a rare lung disease
Official title: Computational Methods for Systems Genetic Analysis of Rare Polygenic Disorder
Funded at Boston Children's Hospital · NIH-11192951 · Data updated 2026-11-12
This study is looking at the genetic causes of Idiopathic Pulmonary Fibrosis (IPF) to find new ways to create better treatments for older adults living with this serious lung condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 25, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $827,753 |
| NIH project number | 1R56HL171620-01 |
| Project ID | NIH-11192951 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with Idiopathic Pulmonary Fibrosis.
✕Less likely to help
Patients with other types of lung diseases or those without a diagnosis of Idiopathic Pulmonary Fibrosis may not benefit from this research.
What this research studies
This research focuses on Idiopathic Pulmonary Fibrosis (IPF), a serious lung condition that affects older adults and has a high mortality rate. The project aims to develop innovative genetic analysis techniques to identify new biological targets for drug development. By utilizing advanced methods such as pleiotropy-informed SNP association tests and Polygenic Risk Scores, the research seeks to better understand the genetic factors contributing to IPF. This could lead to more effective treatments for patients suffering from this rare disorder.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies that significantly improve survival rates and quality of life for patients with IPF.
How similar studies have gone: Previous research has shown promise in using genetic analysis for understanding complex disorders, indicating potential for success in this novel approach.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Chun, Sung — Boston Children's Hospital
- Study coordinator: Chun, Sung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.