New methods for analyzing single cells to understand gene expression and chromatin features
Fast, powerful, scalable, usable, and distributable methods for multi-modal single cell analyses
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11018627
This study is working on new ways to better understand how individual cells behave by looking at their genes and other important features, which could help doctors create more personalized treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11018627 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced methods for analyzing single-cell data, particularly looking at gene expression and chromatin accessibility using techniques like ATAC-seq. By creating a powerful analysis infrastructure called ArchR, the team aims to improve the efficiency and usability of analyzing large-scale single-cell datasets. Patients can benefit from this research as it enhances our understanding of cellular behavior in various health conditions, potentially leading to more personalized treatments. The project will also explore the integration of multiple types of molecular data to provide a comprehensive view of cellular functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve complex cellular behaviors, such as cancer or autoimmune diseases.
Not a fit: Patients with stable, well-understood conditions that do not involve significant cellular heterogeneity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in personalized medicine by improving our understanding of cellular mechanisms in health and disease.
How similar studies have performed: Other research has shown success with similar approaches in single-cell analysis, indicating a promising avenue for further exploration.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREENLEAF, WILLIAM JAMES — STANFORD UNIVERSITY
- Study coordinator: GREENLEAF, WILLIAM JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.