New methods for analyzing RNA molecules in cells
Official title: Direct RNA sequencing using electo-optical zero mode waveguides and custom click fluorescent nucleotides
Funded at Northeastern University · NIH-11044160 · Data updated 2026-11-12
This study is exploring new ways to read RNA directly, which could help us understand how it affects diseases like ALS and frontotemporal degeneration, and it aims to provide valuable insights that might benefit patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 27, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,068,064 |
| NIH project number | 5R01HG013304-02 |
| Project ID | NIH-11044160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or frontotemporal dementia.
✕Less likely to help
Patients with conditions unrelated to RNA modifications or those not diagnosed with ALS or frontotemporal dementia may not benefit from this research.
What this research studies
This research focuses on developing advanced techniques for direct RNA sequencing using innovative optical technologies. By utilizing electro-optical zero mode waveguides and custom fluorescent nucleotides, the project aims to improve the understanding of RNA's role in biological processes, particularly in conditions like amyotrophic lateral sclerosis and frontotemporal degeneration. Patients may benefit from insights gained about RNA modifications and their implications for disease mechanisms. The approach involves analyzing RNA directly without converting it to DNA, allowing for a more accurate representation of RNA's chemical modifications.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new treatments for diseases like ALS and frontotemporal dementia.
How similar studies have gone: Previous research has shown promise in RNA sequencing technologies, indicating potential for success in this novel approach.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Wanunu, Meni — Northeastern University
- Study coordinator: Wanunu, Meni
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.