New method to measure cancer-related protein kinases in cells and tissues
Activity-based Sensor Peptides for Direct, High-throughput, and Kinetic Quantitation of Oncogenic Protein Kinases in Unfractionated Cell and Tissue Samples
This study is working on a new way to measure how certain proteins, important for cell health and often involved in cancer, are working in real-time, which could help scientists find better treatments for cancer and related diseases.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Assayquant Technologies, INC. NIH-funded |
| Lab location | 1 site (Marlborough, United States) |
| Project ID | NIH-11008528 on NIH RePORTER |
What this research studies
This research focuses on developing a novel assay platform to accurately measure the activity of protein kinases, which are crucial for cell function and are often implicated in cancer. The approach utilizes specially designed sensor peptides that can detect phosphorylation events in real-time, providing a more efficient way to evaluate kinase activity in various biological samples. By improving the methods used to study these enzymes, the research aims to enhance drug discovery processes and ultimately lead to better treatment options for patients with cancer and other diseases linked to kinase dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers or diseases associated with abnormal protein kinase activity.
Not a fit: Patients with conditions unrelated to protein kinases or those not currently undergoing treatment for cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for cancer by improving the drug development process targeting protein kinases.
How similar studies have performed: Other research has shown promise in developing similar assay technologies, indicating potential for success in this novel approach.
Where this research is happening
Marlborough, United States
- Assayquant Technologies, INC. — Marlborough, United States (Active)
Researchers
- Principal investigator: Schaefer, Erik Michael — Assayquant Technologies, INC.
- Study coordinator: Schaefer, Erik Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.