New method to control severe bleeding after childbirth.
Official title: Novel Vacuum-Induced Postpartum Hemorrhage Control: a Multicenter Randomized Trial.
Funded at Women and Infants Hospital-Rhode Island · NIH-10908538 · Data updated 2026-11-12
This study is looking at a new way to help women who experience heavy bleeding after giving birth by using a special vacuum method along with a balloon treatment, and it aims to see if this approach works better than the usual care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Women and Infants Hospital-Rhode Island NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $472,708 |
| NIH project number | 5R01HD108210-03 |
| Project ID | NIH-10908538 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who experience severe bleeding after childbirth, particularly those in low and middle-income countries.
✕Less likely to help
Patients who do not experience postpartum hemorrhage or those who have contraindications to balloon tamponade may not benefit from this research.
What this research studies
This research investigates a novel approach to manage postpartum hemorrhage (PPH), a serious condition affecting many women after childbirth. It focuses on using a vacuum-induced method to enhance the effectiveness of uterine balloon tamponade, which is a mechanical intervention used when other treatments fail. The study will involve multiple centers and will compare this new method against standard practices to determine its safety and effectiveness in controlling excessive bleeding. Patients participating in this research will be closely monitored to assess outcomes and improve future care for women experiencing PPH.
Why it matters
Potential benefit: If successful, this research could significantly reduce maternal mortality and morbidity associated with postpartum hemorrhage.
How similar studies have gone: Previous research has shown that uterine balloon tamponade can be effective, but this specific vacuum-induced approach is novel and has not been widely tested.
Where this research is happening
-
Women and Infants Hospital-Rhode Island
Providence, United States Active
Researchers
- Principal investigator: Tuuli, Methodius Gamuo — Women and Infants Hospital-Rhode Island
- Study coordinator: Tuuli, Methodius Gamuo
Related research
Other NIH-funded projects on the same topics.
-
Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
-
Maternal Postpartum Monitoring with a Wearable Sensor (MOMS)
A wearable system called MOMS will continuously monitor multiple physiological signals in pregnant people to detect postpartum hemorrhage earlier than standard vital signs.
-
AI-powered real-time postpartum hemorrhage risk predictor in clinical care
A real-time AI tool integrated into electronic health records helps identify women at risk for postpartum hemorrhage so clinicians can intervene earlier.
-
Targeting Ubiquitination to Improve Uterotonic Therapies in Postpartum Hemorrhage
A new approach aims to boost uterine contractions during childbirth and after delivery by understanding how a hormone receptor is regulated, potentially reducing postpartum hemorrhage risk.
-
Personalized Postpartum Bleeding Risk Prediction with Machine Learning and Genetic Scores
This grant aims to create a personalized tool that predicts a mother’s risk of postpartum hemorrhage using machine learning and her genetic information.
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OPTIMUM OB-TXA: Timing, route, and dose of tranexamic acid to prevent postpartum bleeding before cord clamping
Aims to find the best time, method, and amount of tranexamic acid given before cord clamping to prevent postpartum hemorrhage in new mothers and protect babies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.